MDI was used to test the infant's response to stimuli, hand-eye coordination, language, exploratory activities, cognitive ability, etc. Within 18 months of live births, infants' intelligence development and psychomotor development were measured by Bayley scales of infant development (BSID) (revised edition of Chinese cities), and mental development index (MDI) and psychomotor development index (PDI) were calculated (8). Read more Disabilities that Qualify you for a Service Dog Evaluation Methods According to the level of serum TSH of the pregnant women before labor, they were divided into the hypothyroidism control group, and the serum TSH was kept in the target range through treatment in the uncontrolled hypothyroidism group, the serum TSH was not controlled within the target range due to various reasons, such as the pregnant women's disobedience to the doctor's advice and refusal for treatment. Pregnant women with hypothyroidism will not be treated only FT 3, FT 4, and TSH will be detected every month, and then treated if the disease meets the requirements of SCH or OH. The dosage of levothyroxine sodium tablets had large individual variability, which required clinicians to evaluate factors, such as the cause of hypothyroidism, pre-pregnancy TSH levels, and other factors before treatment, and adjust the dosage according to individual circumstances. The therapeutic target of serum TSH was: 2–3. Triglyceride (TG), total cholesterol (TC), high-density lipoprotein (HDL), and low-density lipoprotein (LDL) were measured.įrom the date of the diagnosis, the pregnant women with SCH and OH were treated with levothyroxine sodium tablets (specification: 50 ug), and FT 3, FT 4, and TSH were detected every 4 weeks. Fasting blood glucose (FBG) and hemoglobin A1c (HbA1c) were measured. The levels of serum-free triiodothyronine (FT 3), free tetraiodothyronine (FT 4), and thyroid-stimulating hormone (TSH) were detected by an automatic chemiluminescence instrument. In the second trimester of pregnancy (14–27 +6 weeks of pregnancy), in the morning, 3 ml of fasting venous blood was collected from all the subjects, and the blood was centrifuged at 3,500 r/5 min for 5 min at room temperature, and the serum was separated. Materials and Methods Object Research Methods In this study, we observed the glucose and lipid metabolism and a pregnancy outcome of pregnant women with hypothyroidism during pregnancy, and followed up the fetus in order to improve the clinical outcome of pregnant women and fetus. In recent years, some scholars have suggested that hypothyroidism during pregnancy may affect maternal glucose and lipid metabolism and offspring development, which seriously endangers maternal and infant health (6). Generally speaking, hypothyroidism is often ignored by people because the onset of hypothyroidism is hidden. The incidence of overt hypothyroidism (OH) in pregnant women is 1–2%, that of subclinical hypothyroidism (SCH) is 2–5%, and that of isolated low T 4 is 8–10% (5). The incidence of hypothyroidism is high among women of childbearing age. Hypothyroidism can lead to a series of related clinical symptoms such as hypometabolism in pregnant women, with listlessness, fatigue, lethargy, pale face, rough skin, and decreased heart rate as the main manifestations (4). During pregnancy, the hypothalamus-pituitary-thyroid regulatory system of pregnant women is in a stress state, and, during pregnancy, it is in a special endocrine state, which leads to the decrease of TH synthesis and the defect of thyroid receptor function, resulting in the decrease of the utilization rate of TH (3). Thyroid hormone (TH) is the most important endocrine hormone in the body, which can promote the synthesis of protein, RNA, DNA, and special enzymes in fetal tissues and cells, TH can regulate the metabolism of carbohydrates, calcium, phosphorus, fat, and other energy substances in pregnant women and fetus, and promote the growth and development of fetal bones and reproductive organs, and is very important to maintain the normal development and maturity of fetus (1, 2). Thyroid dysfunction is one of the common endocrine complications in pregnancy, especially hypothyroidism in pregnancy. Comparison of Fetal Growth and Development Between the Two Groups.Comparison of Adverse Pregnancy Outcomes Between the Two Groups.Comparison of Blood Lipid Levels in Each Group.Comparison of Blood Glucose Levels in Each Group.Incidence of Hypothyroidism During Pregnancy.
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